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| Mariotti,Kristiane de Cássia; Schuh,Roselena Silvestri; Nunes,Jéssica de Matos; Salamoni,Sabrina Pinto; Meirelles,Gabriela; Barreto,Fabiano; Poser,Gilsane Lino Von; Singer,Rodrigo Bustos; Dallegrave,Eliane; Sand,Sueli Teresinha Van Der; Limberger,Renata Pereira. |
| Gunnera perpensa L. (Gunneraceae) is a native South African plant widely used in traditional medicine as an antibacterial and antifungal. In southern Brazil there is the native species called Gunnera manicata L. that also belongs to the Gunneraceae. Nevertheless, there is no information about chemical and pharmacological properties of South American Gunnera species. Therefore this study aimed at assessing the phytochemical and pharmacological profiles of aqueous and methanol Brazilian G. manicata extracts. The results showed that antimicrobial activity in an agar diffusion assay was effective against Staphylococcus aureus and Candida albicans . Phenolic compounds were investigated by liquid chromatography coupled with a tandem mass spectrometer (LC-MS/MS)... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Gunnera manicata L./phytochemistry; Gunnera manicata L./pharmacognosy; Gunneraceae /pharmacognosy; Gunnera manicata L./extracts/antimicrobial effect; Gunnera manicata L./extracts/antioxidant activity; Gunnera manicata L./extracts/antimicrobial assay. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000100015 |
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| Möller,Vanessa Maraschin; Dallegrave,Eliane; Coelho,Ricardo; Pereira,Janaína; Langeloh,Augusto. |
| Avaliou-se a segurança da ivermectina (IVOMEC 1% injetável), um fármaco muito utilizado, administrado a ratas prenhes, no início da fase organogênica, em dosagem até 60 vezes superior (12mg/kg) a utilizada para o tratamento de escabiose em caninos e felinos. Os resultados revelaram ausência de toxicidade sistêmica e reprodutiva, fundamentados na ausência de alterações no desenvolvimento ponderal, consumo de água e ração, absorções embrionárias, massa relativa e exame histopatológico dos órgãos das ratas prenhes, bem como na massa corporal, vitalidade dos fetos, número de fetos por fêmea e alterações macroscópicas externas. Conclui-se pela segurança da ivermectina, quando administrada, em dose única, no início da fase de organogênese de ratas prenhes. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Ivermectina; Toxicidade. |
| Ano: 2003 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-95962003000500003 |
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| Mariotti,Kristiane de Cássia; Schmitt,Gabriela Cristina; Barreto,Fabiano; Fortunato,Rodrigo E.; Singer,Rodrigo B.; Dallegrave,Eliane; Leal,Mirna Bainy; Limberger,Renata Pereira. |
| Gunnera perpensa (Gunneraceae) is an African plant widely used in traditional medicine. This species is known for its activity involving the female reproductive system, such as inducing or increasing labor, treating female infertility, expelling the placenta and/or preventing post-partum hemorrhage. These properties are probably due to (z)-venusol, a majoritary compound, and its action in conjunction with substances in the whole extract and other natural products. In southern Brazil, a native species Gunnera manicata L. that also belongs to Gunneraceae can be found. In spite of the traditional use of G. perpensa, there is no pharmacological and phytochemical information regarding the South American Gunnera species. Therefore, the aim of this study was to... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Gunnera manicata L./pharmacognosy; Gunneraceae/pharmacognosy; Medicinal plants; Uterotrophic assay/experimental study. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000300018 |
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| Schmitt,Gabriela Cristina; Arbo,Marcelo Dutra; Lorensi,Andréia Louise; Jacques,Ana Laura Bemvenuti; Nascimento,Sabrina Nunes do; Mariotti,Kristiane de Cássia; Garcia,Solange Cristina; Dallegrave,Eliane; Leal,Mirna Bainy; Limberger,Renata Pereira. |
| ABSTRACT The association of p-synephrine, ephedrine, salicin, and caffeine in dietary supplements and weight loss products is very common worldwide, even though ephedrine has been prohibited in many countries. The aim of this study was to evaluate a 28-day oral exposure toxicity profile of p-synephrine, ephedrine, salicin, and caffeine mixture (10:4:6:80 w/w respectively) in male and female Wistar rats. Body weight and signs of toxicity, morbidity, and mortality were observed daily. After 28 days, animals were euthanized and blood collected for hematological, biochemical, and oxidative stress evaluation. No clinical signs of toxicity, significant weight loss or deaths occurred, nor were there any significant alterations in hematological parameters.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: P-Synephrine/toxicity profile; Ephedrine/toxicity profile; Salicin/toxicity profile; Caffeine/toxicity profile; Dietary supplements/evaluation; Weight loss products/evaluation.. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000100007 |
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| Bulcão,Rachel Picada; Tonello,Raquel; Piva,Sílvia Juliane; Schmitt,Gabriela Cristina; Emanuelli,Tatiana; Dallegrave,Eliane; Garcia,Solange Cristina. |
| Agrotóxicos e raticidas são responsáveis por inúmeras intoxicações humanas e animais. Dados preliminares sugerem que o uso ilegal desses compostos com a finalidade de intoxicação fatal em pequenos animais é uma prática comum na região central do Estado do Rio Grande do Sul. O Laboratório de Toxicologia (LATOX) recebe amostras de casos em que a principal suspeita é a intoxicação por agrotóxicos ou raticidas (lícitos e ilícitos). O presente estudo teve como objetivo apresentar um levantamento das intoxicações de pequenos animais, analisadas pelo LATOX no período de 2004 a 2008, sendo identificados os xenobióticos por meio de métodos analíticos otimizados pelo laboratório, incluindo screening por cromatografia em camada delgada (CCD) e possível confirmação... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Intoxicação; Cães; Gatos; CCD; CLAE; Carbamatos. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782010000500017 |
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| Mariotti,Kristiane de Cássia; Barreto,Fabiano; Schmitt,Gabriela Cristina; Zancanaro,Ivomar; Dallegrave,Eliane; Singer,Rodrigo Bustos; Leal,Mirna Bainy; Limberger,Renata Pereira. |
| Gunnera (Gunneraceae) forms a complex association with the cyanobacterium Nostoc puctiforme L. Gunnera-Nostoc symbiosis is the only one reported involving a flowering plant, and results in the formation of the neurotoxic amino acid β-N-methylamino-L-alanine (BMAA). The species Gunnera manicata L., for which phytochemical, pharmacological and toxicological studies are lacking, is found in Southern Brazil. Therefore, acute toxicity and the presence of neurotoxic amino acid were investigated in aqueous extracts of G. manicata. The acute toxicity test was conducted by administering aqueous root extract of G. manicata at a concentration of 2000 mg/kg in a single dose orally to Wistar rats. Lethality was monitored daily for 14 days after treatment. The relative... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Gunnera manicata L; /toxicity; Β-N-methylamino-L-alanine/identification; Neurotoxins/identification; Acute toxicity. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000300021 |
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